Distributed(Remote) Test Execution Slave Connection closed in middle of execution

I am using Jmeter version 5.2.1. I have a scenario to simulate 400 parallel logins and inside the test plan I will execute the test samplers for 20 times using loop controller for each users(Threads).

Hence to fast track, I have executed it in remote test execution. Normally 200 Threads with 10 Loop count will take a maximum of 25 mins only. When increasing the loop count to 20, one of the slave node connection closed and the jenkins build went into dead loop.

I am using AWS M5.xLarge instance type. 4 CPU/16 GB RAM. Below is the run command I am using for Jmeter

JVM_ARGS="-Xms2g -Xmx4g -XX:MaxMetaspaceSize=256m"  && export JVM_ARGS && ./jmeter -n -t /home/jenkins/workspace/performance-test-staging-pipeline/test_plans/fd_regression_delight.jmx -e -o /home/jenkins/workspace/fd-performance-test-staging-pipeline/Performance-Report -l /home/jenkins/workspace/fd-performance-test-staging-pipeline/JTL-RPT-986.jtl -R xx.xx.xx.xxx,yy.yy.yy.yyy -Jserver.rmi.ssl.disable=true -Dclient.tries=3 -Gthreads=200

Below is the build log what I can see in Jenkins build console.

summary +   2700 in 00:00:59 =   45.4/s Avg:  3259 Min:    98 Max: 32684 Err:     0 (0.00%) Active: 400 Started: 400 Finished: 0
summary =  52102 in 00:25:38 =   33.9/s Avg:  6542 Min:    81 Max: 139355 Err:     0 (0.00%)

Below is the log I can see in jenkins-server.log

Connection to xx.x.x.xxx closed by remote host.
Connection to xx.x.x.xxx closed.